Hydro-meteorological trigger conditions of debris flows in Austria

Different factors influence the disposition of a watershed for initiation of debris flows, including meteorological trigger conditions as well as the hydrologic and geomorphic disposition. The latter includes slowly changing factors like relief energy or sediment availability, whereas the hydrologic state of a watershed may vary over short time scales. This contribution summarizes the outcomes of a long term project to quantify meteorological and hydrological trigger conditions leading to debris flows at different temporal and spatial scales in the Austrian Alps. The analysis employs a database of more than 4,500 debris flows over the last 100+ years, which is the period for which systematic rainfall data is available. A Bayesian analysis was carried out for determining occurrence probabilities for all Austria. For selected regions, hydrological trigger conditions were assessed using a semi-distributed, conceptual rainfall-runoff model, which was calibrated to measured runoff data. As expected we find increasing trigger probabilities with increasing rainfall amounts and intensities. However, the additional information of regional hydrological parameters as well as their temporal evolution over days prior to a debris-flow event, enables to capture different trigger conditions, including short duration rainstorms, long lasting rainfall events, and snow melt. We also find that a trigger-type resolved prediction of debris-flow susceptibility based on the hydro-meteorological catchment information is superior to simple rainfall-only approaches. The results of this analysis shall improve our understanding of long-term trigger conditions and trends of extreme mass wasting processes in the Alps and aim to become a valuable tool in engineering hazard assessment

Tryptophan- and arginine-rich antimicrobial peptides: Structures and mechanisms of action

AbstractAntimicrobial peptides encompass a number of different classes, including those that are rich in a particular amino acid. An important subset are peptides rich in Arg and Trp residues, such as indolicidin and tritrpticin, that have broad and potent antimicrobial activity. The importance of these two amino acids for antimicrobial activity was highlighted through the screening of a complete combinatorial library of hexapeptides. These residues possess some crucial chemical properties that make them suitable components of antimicrobial peptides. Trp has a distinct preference for the interfacial region of lipid bilayers, while Arg residues endow the peptides with cationic charges and hydrogen bonding properties necessary for interaction with the abundant anionic components of bacterial membranes. In combination, these two residues are capable of participating in cation–π interactions, thereby facilitating enhanced peptide–membrane interactions. Trp sidechains are also implicated in peptide and protein folding in aqueous solution, where they contribute by maintaining native and nonnative hydrophobic contacts. This has been observed for the antimicrobial peptide from human lactoferrin, possibly restraining the peptide structure in a suitable conformation to interact with the bacterial membrane. These unique properties make the Arg- and Trp-rich antimicrobial peptides highly active even at very short peptide lengths. Moreover, they lead to structures for membrane-mimetic bound peptides that go far beyond regular α-helices and β-sheet structures. In this review, the structures of a number of different Trp- and Arg-rich antimicrobial peptides are examined and some of the major mechanistic studies are presented

Impact of climate change on hydro-meteorological trigger conditions for debris flows in Austria

Debris-flow activity is expected to change in a future climate. In this study we connect a susceptibility model for debris-flows on a regional scale with climate projections until 2100. We use this to assess changes of hydro-meteorological trigger conditions for debris flows in six regions in the Austrian Alps. We find limited changes on an annual basis, but distinct changes when separating between hydro-meteorological trigger types and regions. While regions in the east and in the south of Austria may experience less days susceptible to debris flows in summer, there is a general trend of increasing susceptibility earlier in the year for both, rainfall-related and snow-related trigger conditions. The outcomes of this study serve as a basis for the development of adaption strategies for future risk management from this debris-flow hazard

Peripheral Determinants of Oxygen Utilization in Heart Failure With Preserved Ejection Fraction

The aim of this study was to determine the arteriovenous oxygen content difference (ΔAVO2) in adult subjects with and without heart failure with preserved ejection fraction (HFpEF) during systemic and forearm exercise. Subjects with HFpEF had reduced ΔAVO2. Forearm diffusional conductance for oxygen, a lumped conductance parameter that incorporates all impediments to the movement of oxygen from red blood cells in skeletal muscle capillaries into the mitochondria within myocytes, was estimated. Forearm diffusional conductance for oxygen was not different among adults with HFpEF, those with hypertension, and healthy control subjects; therefore, diffusional conductance cannot explain the reduced forearm ΔAVO2. Instead, adiposity was strongly associated with ΔAVO2, suggesting an active role for adipose tissue in reducing exercise capacity in patients with HFpEF

BluePort: A Platform to Study the Eosinophilic Response of Mice to the Bite of a Vector of Leishmania Parasites, Lutzomyia longipalpis Sand Flies

transmission in residents of endemic areas has been attributed to the acquisition of immunity to sand fly salivary proteins. One theoretical way to accelerate the acquisition of this immunity is to increase the density of antigen-presenting cells at the sand fly bite site. Here we describe a novel tissue platform that can be used for this purpose. sand flies. Results presented indicate that a shift in the inflammatory response, from neutrophilic to eosinophilic, is the main histopathological feature associated with the immunity acquired through repeated exposure to the bite of sand flies, and that the BluePort tissue compartment could be used to accelerate this process. In addition, changes observed inside the BluePort parenchyma indicate that it could be used to study complex immunobiological processes, and to develop ectopic secondary lymphoid structures.Understanding the characteristics of the dermal response to the bite of sand flies is a critical element of strategies to control leishmaniasis using vaccines that target salivary proteins. Finding that dermal eosinophilia is such a prominent component of the anti-salivary immunity induced by repeated exposure to sand fly bites raises one important consideration: how to avoid the immunological conflict derived from a protective Th2-driven immunity directed to sand fly saliva with a protective Th1-driven immunity directed to the parasite. The BluePort platform is an ideal tool to address experimentally this conundrum

Severe Asthma Standard-of-Care Background Medication Reduction With Benralizumab: ANDHI in Practice Substudy

Background: The phase IIIb, randomized, parallel-group, placebo-controlled ANDHI double-blind (DB) study extended understanding of the efficacy of benralizumab for patients with severe eosinophilic asthma. Patients from ANDHI DB could join the 56-week ANDHI in Practice (IP) single-arm, open-label extension substudy. Objective: Assess potential for standard-of-care background medication reductions while maintaining asthma control with benralizumab. Methods: Following ANDHI DB completion, eligible adults were enrolled in ANDHI IP. After an 8-week run-in with benralizumab, there were 5 visits to potentially reduce background asthma medications for patients achieving and maintaining protocol-defined asthma control with benralizumab. Main outcome measures for non-oral corticosteroid (OCS)-dependent patients were the proportions with at least 1 background medication reduction (ie, lower inhaled corticosteroid dose, background medication discontinuation) and the number of adapted Global Initiative for Asthma (GINA) step reductions at end of treatment (EOT). Main outcomes for OCS-dependent patients were reductions in daily OCS dosage and proportion achieving OCS dosage of 5 mg or lower at EOT. Results: For non-OCS-dependent patients, 53.3% (n = 208 of 390) achieved at least 1 background medication reduction, increasing to 72.6% (n = 130 of 179) for patients who maintained protocol-defined asthma control at EOT. A total of 41.9% (n = 163 of 389) achieved at least 1 adapted GINA step reduction, increasing to 61.8% (n = 110 of 178) for patients with protocol-defined EOT asthma control. At ANDHI IP baseline, OCS dosages were 5 mg or lower for 40.4% (n = 40 of 99) of OCS-dependent patients. Of OCS-dependent patients, 50.5% (n = 50 of 99) eliminated OCS and 74.7% (n = 74 of 99) achieved dosages of 5 mg or lower at EOT. Conclusions: These findings demonstrate benralizumab's ability to improve asthma control, thereby allowing background medication reduction

Changes of hydro-meteorological trigger conditions for debris flows in a future alpine climate

Debris-flow activity is strongly controlled by hydro-meteorological trigger conditions, which are expected to change in a future climate. In this study we connect a regional hydro-meteorological susceptibility model for debris flows with climate projections until 2100 to assess changes of the frequency of critical trigger conditions for different trigger types (long-lasting rainfall, short-duration storm, snow-melt, rain-on-snow) in six regions in the Austrian Alps. We find limited annual changes of the number of days critical for debris-flow initiation when averaged over all regions, but distinct changes when separating between hydro-meteorological trigger types and study region. Changes become more evident at the monthly/seasonal scale, with a general trend of critical debris-flow trigger conditions earlier in the year. The outcomes of this study serve as a basis for the development of adaption strategies for future risk management.</p

Impact of climate change on hydro-meteorological trigger conditions for debris flows in Austria

Debris-flow activity is expected to change in a future climate. In this study we connect a susceptibility model for debris-flows on a regional scale with climate projections until 2100. We use this to assess changes of hydro-meteorological trigger conditions for debris flows in six regions in the Austrian Alps. We find limited changes on an annual basis, but distinct changes when separating between hydro-meteorological trigger types and regions. While regions in the east and in the south of Austria may experience less days susceptible to debris flows in summer, there is a general trend of increasing susceptibility earlier in the year for both, rainfall-related and snow-related trigger conditions. The outcomes of this study serve as a basis for the development of adaption strategies for future risk management from this debris-flow hazard